the relationship between salivary beta-2 microglobulin and uremia intensity in men with chronic renal failure

objective: this study defines the relationship between salivary beta-2 microglobulin (ß2-m) and intensity of uremia in male patients diagnosed with chronic renal failure (crf). materials and methods: in total of 42 males were enrolled in a case-control study. there were 21 cases of crf and 21 control cases. we collected 10cc of saliva plus 5 cc of blood from all patients to determine ß2-m, blood urea nitrogen (bun) and creatinine (cr) levels. results: there was a correlation between the level of serum bun and salivary urea in controls and patients, which was statistically significant for controls (p=0.028).the correlation between serum and salivary cr was 0.195 in controls (p=0.398) and 0.598 in patients (p=0.006), which was statistically significant in patients. the correlation between serum and saliva was 0.133 (p=0.566) in controls and 0.078 (p=0.737) in patients, which was not statistically significant. the correlation between serum bun and ß2-m was 0.168 (p=0.469) in the control group and 0.629 (p=0.002) in patients, which was statistically significant in patients. the correlation between serum cr and ß2-m was 0.110 (p=0.635) in the control group and 0.678 (p=0.001) in patients, which was statistically significant in patients. the correlation between serum bun and salivary ß2-m was 0.093 (p=0.0690) in controls and 0.152 (p=0.152) in patients, which was not statistically significant. the correlation between serum cr and salivary ß2-m was 0.072 (p=0.070) in the control group and 0.286 (p=0.209) in patients, which was not statistically significant in either group. conclusion: the results of the study indicated that salivary ß2-m cannot be used as a non-invasive indicator to detect the severity of renal failure.